A rapid decrease in kidney function was defined as a decrease in estimated glomerular filtration rate ( gfr ) of at least 6 ml / min per 1 . 73 m per year 以后每4个月.肾脏功能的快速减退被界定为一种评估肾小球滤过率( gfr )的下降，至少为6毫升/每分钟1 . 73米左右。
3.
Although their scr is usually normal , most of the normoalbuminuric diabetic subjects with ckd according to a mdrd e - gfr below 60 do really have a gfr below 60 虽然通常他们的血清肌酐是正常的，但据mdrd （肾脏病膳食改良试验）评估肾小球滤过率在60以下，且有正常蛋白尿、慢性肾病的糖尿病患者gfr确实是在60以下。
4.
Especially , at the site of implantation of day 5 , 6 , uterine stroma cell apposing the preimplantation blastocyst changed into the decidual cells and displayed a distinct immunostaining of phospho mapk . western - blot results showed p44 express stronger than p42 did , with both their peak expression were observed on day 5 , during the period of uterine decidualization 上述结果表明， ma卫k的激活与子宫内膜的接受性及蜕膜的形成有密切关系，推测mapk级联通路激活对蜕膜化十分重要，蜕膜化可能与egf尼gfr直接或间接激活erk有关。
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