We have studied pharmacodynamics of valepotriates through observing its effects on the times of spontaneous motion in mice , the sleep time of sodium pentobarbital ( superthreshold doses ) , sleep rate of sodium pentobarbital ( subthreshold doses ) , the number of writhes induced by acetic acid and seizures rate of metrazol . the experiment results proved that valepotriates could significantly decrease the times of spontaneous motion , prolong the sleep time of sodium pentobarbital ( superthreshold doses ) , enhance the sleep rate of sodium pentobarbital ( subthreshold doses ) , reduce the number of writhes induced by acetic acid and reduce the seizures rate of metrazol , so it showed high central inhibition effect , thus offer scientific foundation for its further exploitation and utilization 通过研究蜘蛛香中总缬草素对小鼠自发活动的影响、对戊巴比妥钠睡眠时间的影响、对戊巴比妥钠阈下剂量的影响、对小鼠扭体反应的影响、对戊四氮诱发惊厥的影响发现：总颗草素能明显抑制小鼠的自主活动，显著延长戊巴比妥钠致小鼠睡眠时间，明显提高阈下剂量戊巴比妥钠小鼠入睡数，对抗戊四氮诱发的小鼠惊厥，显示出较好的中枢抑制作用，为蜘蛛香的进一步研究开发提供了科学依据。
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